The encapsulation of inositol hexaphosphate (IHP), one of the most efficient allosteric effectors of hemoglobin, into red cells (RBC) causes a rightward shift of the hemoglobin oxygen dissociation curve.1 IHP-loaded human erythrocytes display very high P50 values and almost normal functional properties in vitro2, and in vivo life span3; moreover, they seem to deliver oxygen to tissues more efficiently than normal red cells.
Determination of inositol hexaphosphate (IHP) in human IHP-loaded red blood cells by a simple high performance liquid chromatography method / S. Villa, F. Rossi, P.A. Biondi, V. Russo, G. Fiorelli, A. Zanella (ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY). - In: The Use of Resealed Erythrocytes as Carriers and Bioreactors / [a cura di] M. Magnani, J.R. DeLoach. - New York : Plenum Press, 1992. - ISBN 0306443457. - pp. 41-49 [10.1007/978-1-4615-3030-5_5]
Determination of inositol hexaphosphate (IHP) in human IHP-loaded red blood cells by a simple high performance liquid chromatography method
P.A. Biondi;V. Russo;
1992
Abstract
The encapsulation of inositol hexaphosphate (IHP), one of the most efficient allosteric effectors of hemoglobin, into red cells (RBC) causes a rightward shift of the hemoglobin oxygen dissociation curve.1 IHP-loaded human erythrocytes display very high P50 values and almost normal functional properties in vitro2, and in vivo life span3; moreover, they seem to deliver oxygen to tissues more efficiently than normal red cells.Pubblicazioni consigliate
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