The model of promyelocytic leukemia cells HL60 was utilized to study the accumulation of 5-lipoxygenase mRNA during the cellular differentiation induced by DMSO. In the present study a strict correlation between the increase in state of differentiation of HL60 and accumulation of 5-lipoxygenase mRNA is demonstrated, indicating that HL60 cells are an interesting model for the study of drugs which could interfere with the synthesis of the enzyme.
5-Lipoxygenase gene expression in HL60 cells during differentiation with DMSO / G. Piechele, S. Colli, E. Tremoli, A. Maggi. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - 27:1(1993), pp. 53-60.
5-Lipoxygenase gene expression in HL60 cells during differentiation with DMSO
S. ColliSecondo
;E. TremoliPenultimo
;A. MaggiUltimo
1993
Abstract
The model of promyelocytic leukemia cells HL60 was utilized to study the accumulation of 5-lipoxygenase mRNA during the cellular differentiation induced by DMSO. In the present study a strict correlation between the increase in state of differentiation of HL60 and accumulation of 5-lipoxygenase mRNA is demonstrated, indicating that HL60 cells are an interesting model for the study of drugs which could interfere with the synthesis of the enzyme.
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