4-Methylene-5-morpholino-3-phenyl-4,5-dihydroisoxazole (1) reacts with nitrones (2) to give a mixture of diastereoisomeric cycloadducts, namely spiro[isoxazolidine-5,4′-isoxazolines] (3) and (4). The structure and steric configuration of the spiro derivatives have been assigned on the basis of 1H and 13C NMR evidence and by X-ray analysis.
Cycloaddition reactions of nitrones with 4-methylene-5-morpholino-3-phenyl-4,5-dihydroisoxazole : Structure and stereochemical assignments of the products by nuclear magnetic resonance and X-ray analysis / P. Dalla Croce, C. La Rosa, R. Destro. - In: JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS II. - ISSN 0300-9580. - 1990:5(1990 May), pp. 679-683. [10.1039/P29900000679]
Cycloaddition reactions of nitrones with 4-methylene-5-morpholino-3-phenyl-4,5-dihydroisoxazole : Structure and stereochemical assignments of the products by nuclear magnetic resonance and X-ray analysis
P. Dalla CrocePrimo
;C. La RosaSecondo
;R. DestroUltimo
1990
Abstract
4-Methylene-5-morpholino-3-phenyl-4,5-dihydroisoxazole (1) reacts with nitrones (2) to give a mixture of diastereoisomeric cycloadducts, namely spiro[isoxazolidine-5,4′-isoxazolines] (3) and (4). The structure and steric configuration of the spiro derivatives have been assigned on the basis of 1H and 13C NMR evidence and by X-ray analysis.
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