Glucose-6-phosphatase activity in the rat brain in vivo was estimated by measuring the differential loss of tritium and carbon-14 from the glucose pool labeled by a mixture of [2-3H]glucose and [U-14C]glucose. The results provide no evidence of significant dephosphorylation of glucose-6-phosphate and do not support the hypothesis of a futile cycle involving glucose-6-phosphatase activity in the brain.
Reexamination of glucose-6-phosphatase activity in the brain in vivo: no evidence for a futile cycle / T. Nelson, G. Lucignani, S. Atlas, A. M. Crane, G. A. Dienel, L. Sokoloff. - In: SCIENCE. - ISSN 0036-8075. - 229:4708(1985 Jul 05), pp. 60-2-62. [10.1126/science.2990038]
Reexamination of glucose-6-phosphatase activity in the brain in vivo: no evidence for a futile cycle
G. LucignaniSecondo
;
1985
Abstract
Glucose-6-phosphatase activity in the rat brain in vivo was estimated by measuring the differential loss of tritium and carbon-14 from the glucose pool labeled by a mixture of [2-3H]glucose and [U-14C]glucose. The results provide no evidence of significant dephosphorylation of glucose-6-phosphate and do not support the hypothesis of a futile cycle involving glucose-6-phosphatase activity in the brain.
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