The hepatitis C virus (HCV) is frequently associated with mixed cryoglobulinemia (MC), and a number of authors have reported the presence of anti-HCV antibodies and HCV-RNA in the blood of MC patients. The presence of the HCV genome in the blood cells of individuals infected by HCV may correlate with the etiopathology of MC. We investigated the presence of HCV-related sequences in the sera, cryoglobulins and peripheral blood mononuclear cells (PBMC) of patients with MC and of individuals with type C chronic active hepatitis (CAH).

HCV-RNA detection using different PCR methods in sera, cryoglobulins and peripheral blood mononuclear cells of patients with mixed cryoglobulinemia / C. de Maddalena, G. Zehender, A. Bianchi Bosisio, G. Monti, A. Monteverde, F. Invernizzi, M. Galli. - In: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. - ISSN 0392-856X. - 13 Suppl 13:13(1995), pp. S119-S122.

HCV-RNA detection using different PCR methods in sera, cryoglobulins and peripheral blood mononuclear cells of patients with mixed cryoglobulinemia

C. de Maddalena
Primo
;
G. Zehender
Secondo
;
M. Galli
Ultimo
1995

Abstract

The hepatitis C virus (HCV) is frequently associated with mixed cryoglobulinemia (MC), and a number of authors have reported the presence of anti-HCV antibodies and HCV-RNA in the blood of MC patients. The presence of the HCV genome in the blood cells of individuals infected by HCV may correlate with the etiopathology of MC. We investigated the presence of HCV-related sequences in the sera, cryoglobulins and peripheral blood mononuclear cells (PBMC) of patients with MC and of individuals with type C chronic active hepatitis (CAH).
Hepacivirus; Cryoglobulinemia; Humans; Cryoglobulins; RNA, Viral; Polymerase Chain Reaction; Base Sequence; DNA Primers; Molecular Sequence Data; Middle Aged; Monocytes; Female; Male
Settore MED/17 - Malattie Infettive
1995
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/188893
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