New monofunctionalized amphiphilic oligomers, poly (N-vinyl pyrrolidinones) with an hydroxyl end group, were prepared by radical polymerization with 2-isopropoxyethanol, fractionated by both gel-permeation chromatography and fractional precipitation. The terminal hydroxyl group oligomers was activated and reacted with the amino groups of a model peptide, and a protein. These hydroxylated oligomers were also converted to carboxylate end group which were also activated and used as protein and peptide modifying agents.
LOW-MOLECULAR-WEIGHT END-FUNCTIONALIZED POLY(N-VINYLPYRROLIDINONE) FOR THE MODIFICATION OF POLYPEPTIDE AMINOGROUPS / S. L., E. Ranucci, F. P, C. P., S. O., V. F.. - In: JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS. - ISSN 0883-9115. - 9:4(1994), pp. 411-428. [10.1177/088391159400900404]
LOW-MOLECULAR-WEIGHT END-FUNCTIONALIZED POLY(N-VINYLPYRROLIDINONE) FOR THE MODIFICATION OF POLYPEPTIDE AMINOGROUPS
E. Ranucci;
1994
Abstract
New monofunctionalized amphiphilic oligomers, poly (N-vinyl pyrrolidinones) with an hydroxyl end group, were prepared by radical polymerization with 2-isopropoxyethanol, fractionated by both gel-permeation chromatography and fractional precipitation. The terminal hydroxyl group oligomers was activated and reacted with the amino groups of a model peptide, and a protein. These hydroxylated oligomers were also converted to carboxylate end group which were also activated and used as protein and peptide modifying agents.
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