7 individuals who were negative for HIV-1 antibody in a licensed serum enzyme immunoassay (EIA) were positive in a urine EIA and western blot (WB). Follow-up in individuals by use of a cell-mediated immune response showed 1 positive and 1 negative for HIV-1 peptide reactivity. In a second study, 4 out of 5 subjects positive by urine EIA and indeterminate or negative by serum WB were HIV-1 peptide positive in the cell-mediated immune test. Comparison of cell-mediated responses with urine antibody responses may help to resolve discrepant HIV-1 results. Lancet 1993; 342: 1458-59.
HIV-1 antibody serum negativity with urine positivity / H.B. Urnovitz, M. Clerici, G.M. Shearer, T.D. Gottfried, D.J. Robison, L.I. Lutwick, L. Montagnier, D.V. Landers. - In: THE LANCET. - ISSN 0140-6736. - 342:8885(1993), pp. 1458-1459. [10.1016/0140-6736(93)92934-L]
HIV-1 antibody serum negativity with urine positivity
M. ClericiSecondo
;
1993
Abstract
7 individuals who were negative for HIV-1 antibody in a licensed serum enzyme immunoassay (EIA) were positive in a urine EIA and western blot (WB). Follow-up in individuals by use of a cell-mediated immune response showed 1 positive and 1 negative for HIV-1 peptide reactivity. In a second study, 4 out of 5 subjects positive by urine EIA and indeterminate or negative by serum WB were HIV-1 peptide positive in the cell-mediated immune test. Comparison of cell-mediated responses with urine antibody responses may help to resolve discrepant HIV-1 results. Lancet 1993; 342: 1458-59.
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