Increasing numbers of HIV-positive men receiving protease inhibitors (PI) complain of erectile dysfunction (ED). Through the analysis of 334 HIV-1-infected male outpatients, this study shows homosexuality, CD4 cell count, viral load, and indinavir treatment to be independent variables predictive of ED. Furthermore, a neuropathy of the sacral region was detected in 12 patients with ED who underwent diagnostic investigations. For the first time, a PI-containing regimen has been associated with peripheral neuropathy causing ED.
Protease inhibitors and erectile dysfunction. / S. Sollima, M. Osio, F. Muscia, P. Gambaro, A. Alciati, M. Zucconi, T. Maga, F. Adorni, T. Bini, A. d'Arminio Monforte.. - In: AIDS. - ISSN 0269-9370. - 18:17(2001 Nov 23), pp. 2331-2333.
Protease inhibitors and erectile dysfunction.
A. d'Arminio Monforte.Ultimo
2001
Abstract
Increasing numbers of HIV-positive men receiving protease inhibitors (PI) complain of erectile dysfunction (ED). Through the analysis of 334 HIV-1-infected male outpatients, this study shows homosexuality, CD4 cell count, viral load, and indinavir treatment to be independent variables predictive of ED. Furthermore, a neuropathy of the sacral region was detected in 12 patients with ED who underwent diagnostic investigations. For the first time, a PI-containing regimen has been associated with peripheral neuropathy causing ED.
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