In congestive heart failure (CHF), pulmonary gas exchange, as evaluated by carbon monoxide diffusion (DLCO), is impaired. ACE-inhibition improves DLCO. Infusion of saline worsens DLCO, because of upregulated sodium and water transport to the alveolar interstitium, which thickens the alveolar-capillary interface and lengthens the diffusion path for gas exchange. We investigated whether enalapril can readjust the capillary permeability to sodium.
Influence of ACE-inhibition on salt-mediated worsening of pulmonary gas exchange in heart failure / M. Guazzi, R. Brambilla, P. Agostoni, M. D. Guazzi. - In: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. - ISSN 0306-5251. - 51:5(2001 May), pp. 482-7-487.
Influence of ACE-inhibition on salt-mediated worsening of pulmonary gas exchange in heart failure
M. GuazziPrimo
;P. Agostoni;
2001
Abstract
In congestive heart failure (CHF), pulmonary gas exchange, as evaluated by carbon monoxide diffusion (DLCO), is impaired. ACE-inhibition improves DLCO. Infusion of saline worsens DLCO, because of upregulated sodium and water transport to the alveolar interstitium, which thickens the alveolar-capillary interface and lengthens the diffusion path for gas exchange. We investigated whether enalapril can readjust the capillary permeability to sodium.
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