The antispastic drug (R)-(-)-baclofen has been synthesized enantioselectively using a diastereoselective Michael addn. reaction of the conjugate base of an enantiopure Fischer-type amino carbene to p-chloro-nitrostyrene
Enantioselective synthesis of (R)-(-)-baclofen using Fischer-type carbene anions / E. Licandro, S. Maiorana, C. Baldoli, L. Capella, D. Perdicchia. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 11:4(2000), pp. 975-980. [10.1016/S0957-4166(00)00011-2]
Enantioselective synthesis of (R)-(-)-baclofen using Fischer-type carbene anions
E. LicandroPrimo
;S. MaioranaSecondo
;D. PerdicchiaUltimo
2000
Abstract
The antispastic drug (R)-(-)-baclofen has been synthesized enantioselectively using a diastereoselective Michael addn. reaction of the conjugate base of an enantiopure Fischer-type amino carbene to p-chloro-nitrostyrene
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