Labelled 14β-cholest-5-en-3β-ol (14β-[3H]-cholesterol) was synthesized. No conversion into cholesterol was observed by incubation of this sterol with rat liver enzymes. Plasma decay rate, biliary excretion and binding to lipoproteins did not differ from those of the natural stereoisomer. However, significantly different Lecithin Cholesterol Acyl Transferase (LCAT) activity in plasma was observed when 14β-cholesterol was compared with cholesterol
Esterification, lipoprotein binding and excretion of the 14β-stereoisomer of cholesterol / M. Kienle Galli, G. Cighetti, M. Anastasia, C.R. Sirtori. - In: JOURNAL OF STEROID BIOCHEMISTRY. - ISSN 0022-4731. - 9:2(1978), pp. 127-130.
Esterification, lipoprotein binding and excretion of the 14β-stereoisomer of cholesterol
G. CighettiSecondo
;M. AnastasiaPenultimo
;C.R. SirtoriUltimo
1978
Abstract
Labelled 14β-cholest-5-en-3β-ol (14β-[3H]-cholesterol) was synthesized. No conversion into cholesterol was observed by incubation of this sterol with rat liver enzymes. Plasma decay rate, biliary excretion and binding to lipoproteins did not differ from those of the natural stereoisomer. However, significantly different Lecithin Cholesterol Acyl Transferase (LCAT) activity in plasma was observed when 14β-cholesterol was compared with cholesterol
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
