Medullary thyroid carcinoma (MTC) responds very poorly to chemotherapy. Mutations in the RET gene are critical for MTC pathogenesis. RET therefore represents a rational target for the development of novel MTC therapies. The accumulation of evidence from laboratory studies strongly suggests that PP1 inhibitor is a cytostatic agent for cells expressing RET oncoproteins. PP1 functions as a potent and selective inhibitor of RET oncoprotein phosphorylation, promoting its proteasomal degradation.
RETMEN2A and RETMEN2B oncoproteins are targets of PP1 inhibitor / I. Bongarzone, C. Carniti, C. Perego, P. Mondellini, M. A. Pierotti. - In: TUMORI. - ISSN 0300-8916. - 89:5(2003 Sep), pp. 550-2-552.
RETMEN2A and RETMEN2B oncoproteins are targets of PP1 inhibitor
C. Perego;
2003
Abstract
Medullary thyroid carcinoma (MTC) responds very poorly to chemotherapy. Mutations in the RET gene are critical for MTC pathogenesis. RET therefore represents a rational target for the development of novel MTC therapies. The accumulation of evidence from laboratory studies strongly suggests that PP1 inhibitor is a cytostatic agent for cells expressing RET oncoproteins. PP1 functions as a potent and selective inhibitor of RET oncoprotein phosphorylation, promoting its proteasomal degradation.Pubblicazioni consigliate
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