We report the case of a multiple sclerosis (MS) patient without oligoclonal bands (OCB) in three cerebrospinal fluid samples. Restriction fragment length polymorphism analysis of Class 3 genes with radiolabelled specific cDNA probes showed a homozygous deletion of the complement 4A (C4A) genes. Consequent lack of C4A protein can alter the development of humoral immune response probably preventing OCB production. Our observation may suggest a link between a rare immunogenetic pattern and the absence of OCB in MS.
Lack of both spinal fluid oligoclonal bands and complement 4A protein in an MS patient / Franciotta D, Piccolo G, Cuccia M, Bergamaschi R, Zardini E, Melzi d'Eril GV, Dondi E, Cosi V.. - In: ACTA NEUROLOGICA SCANDINAVICA. - ISSN 0001-6314. - 89:1(1994 Jan), pp. 72-74.
Lack of both spinal fluid oligoclonal bands and complement 4A protein in an MS patient
Melzi d'Eril GV;
1994
Abstract
We report the case of a multiple sclerosis (MS) patient without oligoclonal bands (OCB) in three cerebrospinal fluid samples. Restriction fragment length polymorphism analysis of Class 3 genes with radiolabelled specific cDNA probes showed a homozygous deletion of the complement 4A (C4A) genes. Consequent lack of C4A protein can alter the development of humoral immune response probably preventing OCB production. Our observation may suggest a link between a rare immunogenetic pattern and the absence of OCB in MS.
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