A series of isoxazole derivatives structurally related to broxaterol 1 has been prepared and tested for their potency to β1 and β2 adrenergic receptors. At variance with broxaterol, none of the tested compounds displayed agonistic activity. The 3-isopropenyl derivative 5f is the most potent antagonist both in the trachea and atria preparations.
Synthesis and pharmacological characterization of new analogs of broxaterol / M. De Amici, P. Conti, C. Dallanoce, L. Kassi, S. Castellano, G. Stefancich, C. De Micheli. - In: MEDICINAL CHEMISTRY RESEARCH. - ISSN 1054-2523. - 10:2(2000), pp. 69-80.
Synthesis and pharmacological characterization of new analogs of broxaterol
M. De AmiciPrimo
;P. ContiSecondo
;C. Dallanoce;C. De MicheliUltimo
2000
Abstract
A series of isoxazole derivatives structurally related to broxaterol 1 has been prepared and tested for their potency to β1 and β2 adrenergic receptors. At variance with broxaterol, none of the tested compounds displayed agonistic activity. The 3-isopropenyl derivative 5f is the most potent antagonist both in the trachea and atria preparations.
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