To analyze treatment and survival in 34 patients (28 resected) with primary or recurrent retroperitoneal sarcoma (RPS). METHODS: Between July 1994 and January 2001, 34 patients (15M, 19F; mean age: 56 years, range: 25-77) were evaluated. Complete resection was defined as removal of gross tumor with histologically confirmed clear resection margins. RESULTS: Twenty-eight out of 34 patients (82%) (15 were affected by primary RPS, and 13 by recurrent RPS), underwent surgical exploration. Twenty-three patients had a grossly and microscopically complete resection, (3 having a grossly incomplete resection and 2 patients with a grossly complete resection having histologically involved resection margins). Twenty-one out of 28 patients (75%) underwent removal of contiguous intra-abdominal organs. Preoperative mortality was nil, and morbidity occurred in six cases only (21%). High tumor grade results a significant variable for a worse survival in all 28 patients (100% 5 years survival for low grade vs. 0% for high grade; P = 0.0004). Amongst completely resected patients, only histologic grade and peroperative blood transfusions affected disease-free survival (P = 0.04 and P = 0.05, respectively). CONCLUSIONS: An aggressive surgical approach in both primary and recurrent RPS is associated with long-term survival. Copyright 2006 Wiley-Liss, Inc

Primary and recurrent retroperitoneal soft tissue sarcoma : prognostic factors affecting survival / A.C. Chiappa, A.P. Zbar, E. Bertani, R. Biffi, F. Luca, C. Crotti, A. Testori, G. Lazzaro, T. De Pas, U. Pace, B.G. Andreoni. - In: JOURNAL OF SURGICAL ONCOLOGY. - ISSN 0022-4790. - 93:6(2006), pp. 456-463. [10.1002/jso.20446]

Primary and recurrent retroperitoneal soft tissue sarcoma : prognostic factors affecting survival

A.C. Chiappa;C. Crotti;B.G. Andreoni
2006

Abstract

To analyze treatment and survival in 34 patients (28 resected) with primary or recurrent retroperitoneal sarcoma (RPS). METHODS: Between July 1994 and January 2001, 34 patients (15M, 19F; mean age: 56 years, range: 25-77) were evaluated. Complete resection was defined as removal of gross tumor with histologically confirmed clear resection margins. RESULTS: Twenty-eight out of 34 patients (82%) (15 were affected by primary RPS, and 13 by recurrent RPS), underwent surgical exploration. Twenty-three patients had a grossly and microscopically complete resection, (3 having a grossly incomplete resection and 2 patients with a grossly complete resection having histologically involved resection margins). Twenty-one out of 28 patients (75%) underwent removal of contiguous intra-abdominal organs. Preoperative mortality was nil, and morbidity occurred in six cases only (21%). High tumor grade results a significant variable for a worse survival in all 28 patients (100% 5 years survival for low grade vs. 0% for high grade; P = 0.0004). Amongst completely resected patients, only histologic grade and peroperative blood transfusions affected disease-free survival (P = 0.04 and P = 0.05, respectively). CONCLUSIONS: An aggressive surgical approach in both primary and recurrent RPS is associated with long-term survival. Copyright 2006 Wiley-Liss, Inc
Chemotherapy; Radiotherapy; Retroperitoneal sarcoma; Surgery; Survival
Settore MED/18 - Chirurgia Generale
2006
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/18285
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