Pregnant Sprague-Dawley rats received [14C]Carmoisine (200 mg/kg; 25 μCi) by gavage, on days 16-19 of gestation. Animals were killed on day 19 of gestation, 2, 16, 64 h after dosing and blood, maternal tissues, amniotic fluids, placentae, fetal membranes and fetuses were analyzed for radioactivity. No evidence for the transplacental transfer of [14C]Carmoisine or its metabolites was obtained. More than 90% of the radioactivity was excreted in feces and urine within 64 h.
Placental transfer and tissue localization of [14C]carmoisine in the pregnant rat / C.L. Galli, M. Marinovich, L.G. Costa, E. Giavini. - In: TOXICOLOGY LETTERS. - ISSN 0378-4274. - 10:2-3(1982), pp. 255-258.
Placental transfer and tissue localization of [14C]carmoisine in the pregnant rat
C.L. GalliPrimo
;M. MarinovichSecondo
;E. GiaviniUltimo
1982
Abstract
Pregnant Sprague-Dawley rats received [14C]Carmoisine (200 mg/kg; 25 μCi) by gavage, on days 16-19 of gestation. Animals were killed on day 19 of gestation, 2, 16, 64 h after dosing and blood, maternal tissues, amniotic fluids, placentae, fetal membranes and fetuses were analyzed for radioactivity. No evidence for the transplacental transfer of [14C]Carmoisine or its metabolites was obtained. More than 90% of the radioactivity was excreted in feces and urine within 64 h.
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