Age-related reduction in the steady-state levels of messenger RNA for D2(415) and D2(444), the alternatively spliced form of dopamine D2 receptors, was observed in different rat brain areas using the sensitive reverse transcription (RT)-polymerase chain reaction (PCR) technique. In both Sprague-Dawley and Wistar aged rats, the decrease was more pronounced in the D2(444) isoform mRNA thus leading to a changed ratio in striatum as well as in the hippocampus.
Age-related variations in relative abundance of alternative spliced D2 receptor mRNAs in brain areas of two rat strains / F. Della Vedova, F. Fumagalli, G. Sacchetti, G. Racagni, N. Brunello. - In: MOLECULAR BRAIN RESEARCH. - ISSN 0169-328X. - 12:4(1992 Feb), pp. 357-9-359.
Age-related variations in relative abundance of alternative spliced D2 receptor mRNAs in brain areas of two rat strains
F. FumagalliSecondo
;G. RacagniPenultimo
;
1992
Abstract
Age-related reduction in the steady-state levels of messenger RNA for D2(415) and D2(444), the alternatively spliced form of dopamine D2 receptors, was observed in different rat brain areas using the sensitive reverse transcription (RT)-polymerase chain reaction (PCR) technique. In both Sprague-Dawley and Wistar aged rats, the decrease was more pronounced in the D2(444) isoform mRNA thus leading to a changed ratio in striatum as well as in the hippocampus.
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