Metronidazole benzoate, an antiprotozoal drug, forms a 1:1 (mol:mol) inclusion compound with gammacyclodextrin. Phase-solubility analysis, differential scanning calorimetry, X-ray diffraction on powder, and infrared spectra were used in order to characterize the inclusion compound both in solution and in the solid state. The stability of the drug to alkaline hydrolysis was improved in aqueous solutions of gamma-cyclodextrin.
Preparation and characterization of metronidazole benzoate-gammacyclodextrin inclusion compound / F. Giordano, G. Bruni, I.A. Hadi, M. Kata, A. Gazzaniga, G. Bettinetti. - In: BOLLETTINO CHIMICO FARMACEUTICO. - ISSN 0006-6648. - 131:4(1992), pp. 150-156.
Preparation and characterization of metronidazole benzoate-gammacyclodextrin inclusion compound
A. GazzanigaPenultimo
;
1992
Abstract
Metronidazole benzoate, an antiprotozoal drug, forms a 1:1 (mol:mol) inclusion compound with gammacyclodextrin. Phase-solubility analysis, differential scanning calorimetry, X-ray diffraction on powder, and infrared spectra were used in order to characterize the inclusion compound both in solution and in the solid state. The stability of the drug to alkaline hydrolysis was improved in aqueous solutions of gamma-cyclodextrin.
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