In a screening for cancer chemopreventing agents several glycosylglycerols were found to be active. In order to optimize the anti-tumor activity of this class of compounds, a series of 1-O-acyl-2-O-β-D-glucopyranosyl-sn-glycerols differing in the acyl chain length, which varied from C4 to C18 were examined for their in vitro anti-tumor promoting effects on Epstein-Barr virus early antigen (EBV-BA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Among the compounds tested, the monohexanoyl derivative was the most active and, noteworthy, the most potent compound of the glycosylglycerol series hitherto known.
Inhibitory effects of fatty acid monoesters of 2-O-beta-D-glucosylglycerol on Epstein-Barr virus activation / D. Colombo, A. Scala, I. Taino, L. Toma, F. Ronchetti, H. Tokuda, H. Nishino, A. Nagatsu, J. Sakakibara. - In: CANCER LETTERS. - ISSN 0304-3835. - 123:1(1998), pp. 83-86.
Inhibitory effects of fatty acid monoesters of 2-O-beta-D-glucosylglycerol on Epstein-Barr virus activation
D. ColomboPrimo
;A. ScalaSecondo
;F. Ronchetti;
1998
Abstract
In a screening for cancer chemopreventing agents several glycosylglycerols were found to be active. In order to optimize the anti-tumor activity of this class of compounds, a series of 1-O-acyl-2-O-β-D-glucopyranosyl-sn-glycerols differing in the acyl chain length, which varied from C4 to C18 were examined for their in vitro anti-tumor promoting effects on Epstein-Barr virus early antigen (EBV-BA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Among the compounds tested, the monohexanoyl derivative was the most active and, noteworthy, the most potent compound of the glycosylglycerol series hitherto known.
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