When muscimol was injected intraventricularly or intraperitoneally to rats at the dose of 0.6 μg/ventricle and 4 mg/kg, respectively, dihydroxyphenylacetic acid (DOPAC) levels, determined by a radioenzymatic method, were statistically increased in a qualitative similar way in the striatum and olfactory tubercles after both routes of administration. The results, in agreement with other Authors' findings, support the hypothesis of a stimulation of dopamine turnover by muscimol.
Modifications of DOPAC levels in the striatum and olfactory tubercles of the rat after muscimol / A. Restelli, F. Zambotti, L. Vicentini, N. Zonta, P. Mantegazza. - In: PHARMACOLOGICAL RESEARCH COMMUNICATIONS. - ISSN 0031-6989. - 11:1(1979 Jan), pp. 55-59.
Modifications of DOPAC levels in the striatum and olfactory tubercles of the rat after muscimol
L. Vicentini;
1979
Abstract
When muscimol was injected intraventricularly or intraperitoneally to rats at the dose of 0.6 μg/ventricle and 4 mg/kg, respectively, dihydroxyphenylacetic acid (DOPAC) levels, determined by a radioenzymatic method, were statistically increased in a qualitative similar way in the striatum and olfactory tubercles after both routes of administration. The results, in agreement with other Authors' findings, support the hypothesis of a stimulation of dopamine turnover by muscimol.
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