A comprehensive picture of the thermal behaviour of β-cyclodextrin was obtained from experiments involving differential scanning calorimetry (DSC), thermogravimetry (TG), thermomechanical analysis (TMA), and hot stage microscopy (HSM). X-ray powder diffractometry (XRD) was used as a complementary technique to detect solid-solid phase transitions of β- cyclodextrin. Untreated and handled (recrystallized from water, ground, or compacted) samples of commercial β-cyclodextrin showed different thermodynamic and thermomechanical properties. This should be taken into account when β-cyclodextrin is used as a pharmaceutical excipient, particularly in tablet technology, since the physical state and the bulk properties of the powder material may be one of the important factors influencing the characteristics of the dosage form.
Thermal properties and mechanical stress of β-cyclodextrin / G.P. Bettinetti, A. Gazzaniga, F. Giordano, M.E. Sangalli. - In: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. - ISSN 0939-6411. - 40:4(1994), pp. 209-212.
Thermal properties and mechanical stress of β-cyclodextrin
A. GazzanigaSecondo
;M.E. SangalliUltimo
1994
Abstract
A comprehensive picture of the thermal behaviour of β-cyclodextrin was obtained from experiments involving differential scanning calorimetry (DSC), thermogravimetry (TG), thermomechanical analysis (TMA), and hot stage microscopy (HSM). X-ray powder diffractometry (XRD) was used as a complementary technique to detect solid-solid phase transitions of β- cyclodextrin. Untreated and handled (recrystallized from water, ground, or compacted) samples of commercial β-cyclodextrin showed different thermodynamic and thermomechanical properties. This should be taken into account when β-cyclodextrin is used as a pharmaceutical excipient, particularly in tablet technology, since the physical state and the bulk properties of the powder material may be one of the important factors influencing the characteristics of the dosage form.Pubblicazioni consigliate
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