A series of 4-(aryloxy)- and 4-(arylthio)azetidin-2-ones were synthesized by reacting 4-acetoxyazetidin-2-one with phenols or thiophenols and by subsequent alkylation at the nitrogen. The compounds were tested against phytopathogenic fungi of different taxonomic classes in vitro and in vivo. Some of these compounds showed antifungal activity, in particular against Phycomycetes. In general, ethers are slightly more active than thioethers.
Activity of a series of beta-lactams against some phytopathogenic fungi / A. Arnoldi, M.R. Cabrini, G. Farina, L. Merlini. - In: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. - ISSN 0021-8561. - 38:12(1990), pp. 2197-2199. [10.1021/jf00102a019]
Activity of a series of beta-lactams against some phytopathogenic fungi
A. ArnoldiPrimo
;G. FarinaPenultimo
;L. MerliniUltimo
1990
Abstract
A series of 4-(aryloxy)- and 4-(arylthio)azetidin-2-ones were synthesized by reacting 4-acetoxyazetidin-2-one with phenols or thiophenols and by subsequent alkylation at the nitrogen. The compounds were tested against phytopathogenic fungi of different taxonomic classes in vitro and in vivo. Some of these compounds showed antifungal activity, in particular against Phycomycetes. In general, ethers are slightly more active than thioethers.
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