Tecostanine (1) was isolated from Tecoma stans leaves. Its sterochemistry was elucidated as well as its antihyperglycemic activity and its affinity to opioid and nicotinic receptors. The oxalate salt of 1 did not significantly affect blood glucose levels in normoglycaemic and hyperglycaemic rats. It did not appear to interact with opioid receptors (mu type) and showed only moderate affinity to the nicotinic receptor.

Characterization and pharmacological actions of tecostanine, an alkaloid of Tecoma stans / L. Costantino, A. P. Lins, D. Barlocco, F. Celotti, S. A. el-Abady, T. Brunetti, R. Maggi, L. Antolini. - In: PHARMAZIE. - ISSN 0031-7144. - 58:2(2003 Feb), pp. 140-142.

Characterization and pharmacological actions of tecostanine, an alkaloid of Tecoma stans

D. Barlocco;F. Celotti;R. Maggi
Penultimo
;
2003

Abstract

Tecostanine (1) was isolated from Tecoma stans leaves. Its sterochemistry was elucidated as well as its antihyperglycemic activity and its affinity to opioid and nicotinic receptors. The oxalate salt of 1 did not significantly affect blood glucose levels in normoglycaemic and hyperglycaemic rats. It did not appear to interact with opioid receptors (mu type) and showed only moderate affinity to the nicotinic receptor.
Terpenes; Animals; Models, Molecular; Plants, Medicinal; Magnetic Resonance Spectroscopy; Rats; Receptors, Nicotinic; Alkaloids; Rats, Sprague-Dawley; Hypoglycemic Agents; Mexico; Receptors, Opioid; Crystallography, X-Ray; Molecular Conformation; Bignoniaceae; Male
Settore BIO/09 - Fisiologia
Settore MED/04 - Patologia Generale
Settore CHIM/08 - Chimica Farmaceutica
feb-2003
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/181408
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