Purging procedures are increasingly used to provide stem cell collections devoid of contaminating tumor cells. In follicle center lymphoma (FCL), most approaches eradicate polymerase chain reaction (PCR);-detectable disease in only a fraction of harvests undergoing ex vivo manipulation. In this study we evaluated whether there is a relationship between tumor burden of stem cell harvests and successful clearance of PCR-detectable disease following ex vivo manipulation.
A validated real-time quantitative PCR approach shows a correlation between tumor burden and successful ex vivo purging in follicular lymphoma patients / M. Ladetto, S. Sametti, J. W. Donovan, D. Ferrero, M. Astolfi, M. Mitterer, I. Ricca, D. Drandi, P. Corradini, P. Coser, A. Pileri, J. G. Gribben, C. Tarella. - In: EXPERIMENTAL HEMATOLOGY. - ISSN 0301-472X. - 29:2(2001 Feb), pp. 183-93-193. [10.1016/S0301-472X(00)00651-2]
A validated real-time quantitative PCR approach shows a correlation between tumor burden and successful ex vivo purging in follicular lymphoma patients
P. Corradini;C. Tarella
2001
Abstract
Purging procedures are increasingly used to provide stem cell collections devoid of contaminating tumor cells. In follicle center lymphoma (FCL), most approaches eradicate polymerase chain reaction (PCR);-detectable disease in only a fraction of harvests undergoing ex vivo manipulation. In this study we evaluated whether there is a relationship between tumor burden of stem cell harvests and successful clearance of PCR-detectable disease following ex vivo manipulation.Pubblicazioni consigliate
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