Minimum inhibitory concentrations (MIC) for Botrytis cinerea and Saccharomyces cerevisiae with ketoconazole were 10 μg ml- 1 and 20 μg ml- 1, respectively. The time-course of inhibition with treatment at the MIC was examined for each organism and the sterol profile determined. Botrytis cinerea initially accumulated 24-methylene-24(25)-dihydrolanosterol and then obtusifolione during growth arrest. Saccharomyces cerevisiae initially accumulated lanosterol with subsequent production of 3,6 diol, just prior to growth arrest.
Ketoconazole-mediated growth inhibition in Botrytis cinerea and Saccharomyces cerevisiae / M.A. Quail, A. Arnoldi, D.J. Moore, M.W. Goosey, S.L. Kelley. - In: PHYTOCHEMISTRY. - ISSN 0031-9422. - 32:2(1993), pp. 273-280.
Ketoconazole-mediated growth inhibition in Botrytis cinerea and Saccharomyces cerevisiae
A. ArnoldiSecondo
;
1993
Abstract
Minimum inhibitory concentrations (MIC) for Botrytis cinerea and Saccharomyces cerevisiae with ketoconazole were 10 μg ml- 1 and 20 μg ml- 1, respectively. The time-course of inhibition with treatment at the MIC was examined for each organism and the sterol profile determined. Botrytis cinerea initially accumulated 24-methylene-24(25)-dihydrolanosterol and then obtusifolione during growth arrest. Saccharomyces cerevisiae initially accumulated lanosterol with subsequent production of 3,6 diol, just prior to growth arrest.
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