The use of beta-cyclodextrin for the preparation of pellets by the extrusion/spheronization process is described for different formulations and processing conditions. Sieve analysis and friability tests were performed to assess the physical and technological characteristics of pellets. Satisfactory products were obtained with beta-cyclodextrin contents up to 90% by weight.
The use of beta-cyclodextrin as a pelletization agent in the extrusion/spheronization process / A. Gazzaniga, M.E. Sangalli, G. Bruni, L. Zema, C. Vecchio, F. Giordano. - In: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY. - ISSN 0363-9045. - 24:9(1998 Sep), pp. 869-873.
The use of beta-cyclodextrin as a pelletization agent in the extrusion/spheronization process
A. GazzanigaPrimo
;M.E. SangalliSecondo
;L. Zema;
1998
Abstract
The use of beta-cyclodextrin for the preparation of pellets by the extrusion/spheronization process is described for different formulations and processing conditions. Sieve analysis and friability tests were performed to assess the physical and technological characteristics of pellets. Satisfactory products were obtained with beta-cyclodextrin contents up to 90% by weight.
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