Two alkaloids 1 and 2 were isolated from the seeds of Erythrophleum lasianthum. Their structures were assigned by spectroscopic and chemical means as 3 beta-hydroxynorerythrosuamine (1) and its 3-O-beta-D-glucopyranoside (2). In spontaneously beating atria, both compounds 1 and 2 showed a marked and concentration-dependent positive inotropic activity and a weak negative chronotropic activity. The positive inotropic effect induced by 1 and 2 was not modified by propranolol, prazosin, carbachol, and ranitidine plus pyrilamine. Both 1 and 2 were very active in inhibiting the Na+/K+-ATPase isolated from bovine cardiac sarcolemmal vesicles.
Chemical and pharmacological characterization of Erythrophleum lasianthum alkaloids / L. VEROTTA, T. ABURJAI, C.B. ROGERS, P. DORIGO, I. MARAGNO, D. FRACCAROLLO, G. SANTOSTASI, R.M. GAION, M. FLOREANI, F. CARPENEDO. - In: PLANTA MEDICA. - ISSN 0032-0943. - 61:3(1995), pp. 271-274.
Chemical and pharmacological characterization of Erythrophleum lasianthum alkaloids
L. VEROTTAPrimo
;
1995
Abstract
Two alkaloids 1 and 2 were isolated from the seeds of Erythrophleum lasianthum. Their structures were assigned by spectroscopic and chemical means as 3 beta-hydroxynorerythrosuamine (1) and its 3-O-beta-D-glucopyranoside (2). In spontaneously beating atria, both compounds 1 and 2 showed a marked and concentration-dependent positive inotropic activity and a weak negative chronotropic activity. The positive inotropic effect induced by 1 and 2 was not modified by propranolol, prazosin, carbachol, and ranitidine plus pyrilamine. Both 1 and 2 were very active in inhibiting the Na+/K+-ATPase isolated from bovine cardiac sarcolemmal vesicles.
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