The synthesis of 5-(indol-2'-yl)pyridin-2-ones and 5-(indol-2'-yl)pyran-2-one by Pd-catalyzed reactions is described. The best results are obtained using 2-indolylstannanes or 2-indolylzinc halides to be coupled with 5-bromopyridin-2-ones or 5-bromopyran-2-one in the presence of Pd(PPh3)(4) catalyst. Other Pd-catalyzed reactions are discussed. (C) 1998 Elsevier Science Ltd. All rights reserved.
Application of the Pd-catalyzed heteroarylation to the synthesis of 5-(indol-2 '-yl)pyridin-2-one and 5-(indol-2 '-yl)pyran-2-one / B. Danieli, G. Lesma, M. Martinelli, D. Passarella, I. Peretto, A. Silvani. - In: TETRAHEDRON. - ISSN 0040-4020. - 54:46(1998), pp. 14081-14088.
Application of the Pd-catalyzed heteroarylation to the synthesis of 5-(indol-2 '-yl)pyridin-2-one and 5-(indol-2 '-yl)pyran-2-one
B. DanieliPrimo
;G. LesmaSecondo
;D. Passarella;A. SilvaniUltimo
1998
Abstract
The synthesis of 5-(indol-2'-yl)pyridin-2-ones and 5-(indol-2'-yl)pyran-2-one by Pd-catalyzed reactions is described. The best results are obtained using 2-indolylstannanes or 2-indolylzinc halides to be coupled with 5-bromopyridin-2-ones or 5-bromopyran-2-one in the presence of Pd(PPh3)(4) catalyst. Other Pd-catalyzed reactions are discussed. (C) 1998 Elsevier Science Ltd. All rights reserved.
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