The synthesis of two S-proline derivatives is described together with their use as chiral ligands for lithium in reactions of n-butyllithium with benzaldehyde to give 1-phenyl-1-pentanol with moderate optical purity. The presence of lithium salts in the reaction mixture causes a decrease in asymmetric induction. © 1982.
Enantioselective synthesis of secondary alcohols in the presence of chiral ligands / L. Colombo, C.M.A. Gennari, G. Poli, C. Scolastico. - In: TETRAHEDRON. - ISSN 0040-4020. - 38:17(1982), pp. 2725-2727. [10.1016/0040-4020(82)80029-X]
Enantioselective synthesis of secondary alcohols in the presence of chiral ligands
C.M.A. Gennari;C. Scolastico
1982
Abstract
The synthesis of two S-proline derivatives is described together with their use as chiral ligands for lithium in reactions of n-butyllithium with benzaldehyde to give 1-phenyl-1-pentanol with moderate optical purity. The presence of lithium salts in the reaction mixture causes a decrease in asymmetric induction. © 1982.
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