MgBr2 mediated addition of Methyl α-methylthio propionate silylketene acetal to α and α,β-alkoxy aldehydes is highly 3,4 -selective (18:1). -α- methylene-β- hydroxy-∂-alkoxy esters (6) and (8) are synthesized.
LEWIS ACID PROMOTED ALDOL ADDITIONS OF ALPHA-THIOSILYLKETENE ACETALS TO ALPHA-ALKOXY ALDEHYDES - DIASTEREOSELECTIVE SYNTHESIS OF SYN-ALPHA-METHYLENE-BETA-HYDROXY-GAMMA-ALKOXY ESTERS / A. Bernardi, S. Cardani, C.M.A. Gennari, G. Poli, C. Scolastico. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 26:52(1985), pp. 6509-6512. [10.1016/S0040-4039(00)99039-7]
LEWIS ACID PROMOTED ALDOL ADDITIONS OF ALPHA-THIOSILYLKETENE ACETALS TO ALPHA-ALKOXY ALDEHYDES - DIASTEREOSELECTIVE SYNTHESIS OF SYN-ALPHA-METHYLENE-BETA-HYDROXY-GAMMA-ALKOXY ESTERS
A. BernardiPrimo
;C.M.A. Gennari;C. ScolasticoUltimo
1985
Abstract
MgBr2 mediated addition of Methyl α-methylthio propionate silylketene acetal to α and α,β-alkoxy aldehydes is highly 3,4 -selective (18:1). -α- methylene-β- hydroxy-∂-alkoxy esters (6) and (8) are synthesized.
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