Numerous investigations have found a relationship between higher risk of cancer and increased intake of fats, while results of clinical studies of fat reduction and breast cancer recurrence have been mixed. A diet completely free of fats cannot be easily administered to humans, but experimental studies in mice can be done to determine whether this extreme condition influences tumor development. Here, we examined the effects of a FA-free diet on mammary tumor development and growth rate in female FVB-neu proto-oncogene transgenic mice that develop spontaneous multifocal mammary tumors after a long latency period. Mice were fed a fatty acid-free diet beginning at 112, 35, and 30 days of age. In all these experiments, tumor appearance was delayed, tumor incidence was reduced and the mean number of palpable mammary tumors per mouse was lower, as compared to standard diet-fed mice. By contrast, tumor growth rate was unaffected in mice fed the fatty acid-free diet. Plasma of mice fed the fatty acid-free diet revealed significantly higher contents of oleic, palmitoleic and 20:3?9 acids and lower contents of linoleic and palmitic acids. In conclusion, these findings indicate that a FA-free diet reduces tumor incidence and latency but not tumor growth rate, suggesting that a reduction in dietary FAs in humans may have a protective effect on tumorigenesis but not on tumors once they appear.

Influence of fatty acid-free diet on mammary tumor development and growth rate in HER-2/neu transgenic mice / A. Rossini, L. Zanobbio, L. Sfondrini, A. Cavalleri, G. Secreto, D. Morelli, M. Palazzo, M. Sommariva, E. Tagliabue, C. Rumio, A. Balsari. - In: JOURNAL OF CELLULAR PHYSIOLOGY. - ISSN 0021-9541. - 228:1(2013 Jan), pp. 242-249. [10.1002/Jcp.24130]

Influence of fatty acid-free diet on mammary tumor development and growth rate in HER-2/neu transgenic mice

A. Rossini
Primo
;
L. Zanobbio
Secondo
;
L. Sfondrini;M. Palazzo;M. Sommariva;C. Rumio
Penultimo
;
A. Balsari
Ultimo
2013

Abstract

Numerous investigations have found a relationship between higher risk of cancer and increased intake of fats, while results of clinical studies of fat reduction and breast cancer recurrence have been mixed. A diet completely free of fats cannot be easily administered to humans, but experimental studies in mice can be done to determine whether this extreme condition influences tumor development. Here, we examined the effects of a FA-free diet on mammary tumor development and growth rate in female FVB-neu proto-oncogene transgenic mice that develop spontaneous multifocal mammary tumors after a long latency period. Mice were fed a fatty acid-free diet beginning at 112, 35, and 30 days of age. In all these experiments, tumor appearance was delayed, tumor incidence was reduced and the mean number of palpable mammary tumors per mouse was lower, as compared to standard diet-fed mice. By contrast, tumor growth rate was unaffected in mice fed the fatty acid-free diet. Plasma of mice fed the fatty acid-free diet revealed significantly higher contents of oleic, palmitoleic and 20:3?9 acids and lower contents of linoleic and palmitic acids. In conclusion, these findings indicate that a FA-free diet reduces tumor incidence and latency but not tumor growth rate, suggesting that a reduction in dietary FAs in humans may have a protective effect on tumorigenesis but not on tumors once they appear.
olive oil diet; high corn-oil; breast-cancer; caloric restriction; energy restriction; gene-expression; promotion phase; cell-function; carcinogenesis; tumorigenesis
Settore MED/04 - Patologia Generale
Settore BIO/17 - Istologia
gen-2013
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/175662
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