SPECT studies of regional cerebral perfusion with a high-resolution system were compared to PET studies of regional cerebral glucose utilization (rCMRglc) in 21 patients with probable Alzheimer's disease (AD). Ten normal subjects were also evaluated with SPECT and 10 with PET. METHODS: rCMRglc (for PET) and counts (for SPECT) in the associative cortices were normalized to the average rCMRglc, and counts in the calcarine cortex and basal ganglia were considered as a "reference area" to obtain a ratio. The ratio differences between patients and controls were tested with ANOVA performed separately for PET and SPECT. RESULTS: The difference between probable AD patients and controls was significant for both PET (p < 0.00001) and SPECT (p < 0.005); this difference was significant for the frontal, temporal and parietal cortices (p < 0.0001) for PET, and for the temporal (p < 0.005) and parietal (p < 0.001) cortices for SPECT. Temporo-parietal defects were detected in all subjects with PET and in 90% with SPECT. CONCLUSION: PET and SPECT are able to detect characteristic temporo-parietal abnormalities in probable AD. However, the presence of abnormalities in other associative areas is better evaluated with PET.

High-resolution technetium-99m-HMPAO SPECT in patients with probable Alzheimer's disease : comparison with fluorine-18-FDG PET / C. Messa, D. Perani, G. Lucignani, G.A. Zenorini, F. Zito, G. Rizzo, F. Grassi, A. Del Sole, M. Franceschi, M.C. Gilardi, F. Fazio. - In: THE JOURNAL OF NUCLEAR MEDICINE. - ISSN 0161-5505. - 35:2(1994), pp. 210-216.

High-resolution technetium-99m-HMPAO SPECT in patients with probable Alzheimer's disease : comparison with fluorine-18-FDG PET

G. Lucignani;G. Rizzo;A. Del Sole;
1994

Abstract

SPECT studies of regional cerebral perfusion with a high-resolution system were compared to PET studies of regional cerebral glucose utilization (rCMRglc) in 21 patients with probable Alzheimer's disease (AD). Ten normal subjects were also evaluated with SPECT and 10 with PET. METHODS: rCMRglc (for PET) and counts (for SPECT) in the associative cortices were normalized to the average rCMRglc, and counts in the calcarine cortex and basal ganglia were considered as a "reference area" to obtain a ratio. The ratio differences between patients and controls were tested with ANOVA performed separately for PET and SPECT. RESULTS: The difference between probable AD patients and controls was significant for both PET (p < 0.00001) and SPECT (p < 0.005); this difference was significant for the frontal, temporal and parietal cortices (p < 0.0001) for PET, and for the temporal (p < 0.005) and parietal (p < 0.001) cortices for SPECT. Temporo-parietal defects were detected in all subjects with PET and in 90% with SPECT. CONCLUSION: PET and SPECT are able to detect characteristic temporo-parietal abnormalities in probable AD. However, the presence of abnormalities in other associative areas is better evaluated with PET.
single-photon emission computed tomography ; positron emission tomography ; alzheimers disease ; fluorine-18-fluorodeoxyglucose
Settore MED/36 - Diagnostica per Immagini e Radioterapia
Settore MED/26 - Neurologia
1994
http://jnm.snmjournals.org/content/35/2/210.long
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/175601
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