The immunogenicity and reactogenicity of a recombinant hepatitis B vaccine was evaluated in 792 healthy 12 years olds. Three doses were administered (time 0,1,6 months); blood samples and self administered questionaries on reactogenicity were collected in a 9 month period. At the time of the first vaccine injection anti-HBc was detected in only three (0.37%) of the subjects. A protective antibody titer (>10mIU/ml) was present in 781 (98.6%) at 9 months (Geometric Mean Titer, GMT, 2951mIU/ml). Only mild local reactions and rare general symptoms were noted. These data confirme the safety and efficacy of this vaccination in Italian adolescents.
Immune response to recombinant b vaccine in school aged children under field conditions / F. Pregliasco, G. Grilli, C. Mensi, A. Andreassi, E. D'Addezio, F. Vacca, L. Nacciariti, A.R. Zanetti, M.L. Profeta. - In: JOURNAL OF PREVENTIVE MEDICINE AND HYGIENE. - ISSN 1121-2233. - 36:3-4(1995), pp. 131-135.
Immune response to recombinant b vaccine in school aged children under field conditions
F. Pregliasco;C. Mensi;A.R. Zanetti;
1995
Abstract
The immunogenicity and reactogenicity of a recombinant hepatitis B vaccine was evaluated in 792 healthy 12 years olds. Three doses were administered (time 0,1,6 months); blood samples and self administered questionaries on reactogenicity were collected in a 9 month period. At the time of the first vaccine injection anti-HBc was detected in only three (0.37%) of the subjects. A protective antibody titer (>10mIU/ml) was present in 781 (98.6%) at 9 months (Geometric Mean Titer, GMT, 2951mIU/ml). Only mild local reactions and rare general symptoms were noted. These data confirme the safety and efficacy of this vaccination in Italian adolescents.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
