Pulmonary and chest wall mechanics were studied in 18 anesthetized paralyzed supine humans by use of the technique of rapid airway occlusion during constant-flow inflation. Analysis of the changes in transpulmonary pressure after flow interruption allowed partitioning of the overall resistance of the lung (RL) into two compartments, one (Rint,L) reflecting airway resistance and the other (ΔRL) representing the viscoelastic properties of the pulmonary tissues. Similar analysis of the changes in esophageal pressure indicates that chest wall resistance (Rw) was due entirely to the viscoelastic properties of the chest wall tissues (ΔRw = Rw). In line with previous measurements of airway resistance, Rint,L increased with increasing flow and decreased with increasing volume. The opposite was true for both ΔRL and ΔRw. This behavior was interpreted in terms of a viscoelastic model that allowed computation of the viscoelastic constants of the lung and chest wall. This model also accounts for frequency, volume, and flow dependence of elastance of the lung and chest wall. Static and dynamic elastances, as well as ΔR, were higher for the lung than for the chest wall.

Pulmonary and chest wall mechanics in anesthetized paralyzed humans / E. D'Angelo, F.M. Robatto, E. Calderini, M. Tavola, D. Bono, G. Torri, J. Milic-Emili. - In: JOURNAL OF APPLIED PHYSIOLOGY. - ISSN 8750-7587. - 70:6(1991), pp. 2602-2610.

Pulmonary and chest wall mechanics in anesthetized paralyzed humans

F.M. Robatto
Secondo
;
1991

Abstract

Pulmonary and chest wall mechanics were studied in 18 anesthetized paralyzed supine humans by use of the technique of rapid airway occlusion during constant-flow inflation. Analysis of the changes in transpulmonary pressure after flow interruption allowed partitioning of the overall resistance of the lung (RL) into two compartments, one (Rint,L) reflecting airway resistance and the other (ΔRL) representing the viscoelastic properties of the pulmonary tissues. Similar analysis of the changes in esophageal pressure indicates that chest wall resistance (Rw) was due entirely to the viscoelastic properties of the chest wall tissues (ΔRw = Rw). In line with previous measurements of airway resistance, Rint,L increased with increasing flow and decreased with increasing volume. The opposite was true for both ΔRL and ΔRw. This behavior was interpreted in terms of a viscoelastic model that allowed computation of the viscoelastic constants of the lung and chest wall. This model also accounts for frequency, volume, and flow dependence of elastance of the lung and chest wall. Static and dynamic elastances, as well as ΔR, were higher for the lung than for the chest wall.
Settore BIO/09 - Fisiologia
Settore MED/41 - Anestesiologia
1991
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/171696
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