To evaluate the prognostic value of proliferative maker Ki-67, its expression was determined immunohistochemically in 37 gallbladder carcinomas (GBCs). A high Ki-67 index was significantly correlated with tumor lymphatic invasion (P=0.007) and vascular invasion (P=0.04). High Ki-67 index group and low Ki-67 index group showed different clinical courses. Five patients who experienced recurrences in high Ki-67 index group developed their recurrent diseases within one year after surgery and died soon after recurrence, while the recurrences (five cases) in low Ki-67 index group were distributed all stages after surgery. In conclusion, high Ki-67 index predicts early recurrence after surgery for GBCs
Proliferative marker Ki-67 in gallbladder carcinomas: high expression level predicts early recurrence after surgical resection / A. M. Hui, Y. Z. Shi, X. Li, L. Sun, G. Torzilli, T. Takayama, M. Makuuchi. - In: CANCER LETTERS. - ISSN 0304-3835. - 176:2(2002 Feb 25), pp. 191-198.
Proliferative marker Ki-67 in gallbladder carcinomas: high expression level predicts early recurrence after surgical resection
G. Torzilli;
2002
Abstract
To evaluate the prognostic value of proliferative maker Ki-67, its expression was determined immunohistochemically in 37 gallbladder carcinomas (GBCs). A high Ki-67 index was significantly correlated with tumor lymphatic invasion (P=0.007) and vascular invasion (P=0.04). High Ki-67 index group and low Ki-67 index group showed different clinical courses. Five patients who experienced recurrences in high Ki-67 index group developed their recurrent diseases within one year after surgery and died soon after recurrence, while the recurrences (five cases) in low Ki-67 index group were distributed all stages after surgery. In conclusion, high Ki-67 index predicts early recurrence after surgery for GBCsPubblicazioni consigliate
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