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Please use this identifier to cite or link to this item:http://hdl.handle.net/2434/169003
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| Title: | Activation of the orphan nuclear receptor RORα induces growth arrest in androgen-independent DU 145 prostate cancer cells |
| Authors: | MORETTI, ROBERTA MANUELA
MONTAGNANI MARELLI, MARINA
MOTTA, MARCELLA
LIMONTA, PATRIZIA |
| Abstract: | RORalpha is a transcription factor which belongs to the family of orphan nuclear receptors. The regulatory functions of this receptor are still poorly understood. However, response elements for RORalpha are present on the promoter of cell cycle-related genes suggesting that it might be involved in the control of cell proliferation. In this study, we investigated the expression and the possible function of RORalpha in a human androgen-independent prostate cancer cell line (DU 145). The thiazolidinedione-derivative CGP 52608 has been utilized as the specific ligand and activator of RORalpha. |
| Keywords: | Receptors, Cytoplasmic and Nuclear ; Animals ; Thiosemicarbazones ; Antineoplastic Agents ; Dose-Response Relationship, Drug ; Thiazoles ; Humans ; Cyclin-Dependent Kinase Inhibitor p21 ; Mice ; Mice, Nude ; Reverse Transcriptase Polymerase Chain Reaction ; Gene Expression Regulation, Neoplastic ; Tumor Cells, Cultured; Nuclear Receptor Subfamily 1, Group F, Member 1 ; Transplantation, Heterologous ; Trans-Activators; Prostatic Neoplasms ; Cell Cycle ; Ligands ; Male; Cell Division ; Cyclins |
| MIUR subjects: | BIO/13 - Biologia Applicata
BIO/09 - Fisiologia |
| Publication date: | 1-Mar-2001 |
| Digital Object Identifier (DOI): | 10.1002/1097-0045(20010301)46:4<327::AID-PROS1040>3.0.CO;2-6 |
| Citation: | Activation of the orphan nuclear receptor RORα induces growth arrest in androgen-independent DU 145 prostate cancer cells / R.M. Moretti, M. Montagnani Marelli, M. Motta, D. Polizzi, S. Monestiroli, G. Pratesi, P. Limonta. - In: Prostate. - ISSN 0270-4137. - ISSN 1097-0045. - 46:4(2001 Mar 01), pp. 327-335. |
| Type: | Article (author) |
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Files in This Item:
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| Prostate 2001-1040_ftp.pdf | Post-print (versione accettata dall'editore) | 155.85 kB | Adobe PDF | View/Open
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