Silver catalysed/microwave assisted domino reactions of 2-alkynyl-acetophenones and 3-acetyl-2-alkynylpyridines in the presence of ammonia are widely described. In most cases the reaction give a mixture of the imino- and carbo-cyclisation products, with a general preference for the former. A plausible mechanism is proposed and the dual activity of silver salts is supported by NMR experiments.
Silver-catalysed intramolecular cyclisation of 2-alkynylacetophenones and 3-acetyl-2-alkynylpyridines in the presence of ammonia / M. Dell'Acqua, G. Abbiati, A. Arcadi, E. Rossi. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - 9:22(2011 Oct 26), pp. 7836-7848.
Silver-catalysed intramolecular cyclisation of 2-alkynylacetophenones and 3-acetyl-2-alkynylpyridines in the presence of ammonia
M. Dell'AcquaPrimo
;G. Abbiati
;E. RossiUltimo
2011
Abstract
Silver catalysed/microwave assisted domino reactions of 2-alkynyl-acetophenones and 3-acetyl-2-alkynylpyridines in the presence of ammonia are widely described. In most cases the reaction give a mixture of the imino- and carbo-cyclisation products, with a general preference for the former. A plausible mechanism is proposed and the dual activity of silver salts is supported by NMR experiments.
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