The acute administration of a tryptophan-free amino acid diet to rats has previously been reported to produce a marked reduction in brain serotonin concentrations. The present study examined the effects of such a diet on electroencephalographic sleep measures. There was a decrease in REM sleep and a small increase in nonREM sleep, with no change in total sleep time. In view of these and other observations, the hypothesis that the serotonergic system plays an important role in the maintenance of nonREM sleep should be carefully reevaluated.
Reduction of REM-sleep by a tryptophan-free amino acid diet / E.A. Moja, W.B. Mendelson, D.M. Stoff, J.C. Gillin, R.J. Wyatt. - In: LIFE SCIENCES. - ISSN 0024-3205. - 24:16(1979 Apr 16), pp. 1467-1470.
Reduction of REM-sleep by a tryptophan-free amino acid diet
E.A. MojaPrimo
;
1979
Abstract
The acute administration of a tryptophan-free amino acid diet to rats has previously been reported to produce a marked reduction in brain serotonin concentrations. The present study examined the effects of such a diet on electroencephalographic sleep measures. There was a decrease in REM sleep and a small increase in nonREM sleep, with no change in total sleep time. In view of these and other observations, the hypothesis that the serotonergic system plays an important role in the maintenance of nonREM sleep should be carefully reevaluated.Pubblicazioni consigliate
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