The use of pharmaceutically active natural products as building blocks for the generation of new entities is a challenging strategy for the exploration of the chemical space. The presentation will regard three different topics: a) Synthesis of new camptothecin derivatives obtained by modification of position 20, b) Tubulin assisted dynamic combinatorial library of thiocolchicine-podophyllotoxin conjugates and c) Flow total synthesis of (+)-dumetorine and natural congeners
Anticancer and Antiangiogenesis Compounds: Natural Products as Building Blocks / D. Passarella. ((Intervento presentato al convegno Chemical Biology with Natural Products Cost Action CM0804 Workshop tenutosi a Crete nel 2010.
Anticancer and Antiangiogenesis Compounds: Natural Products as Building Blocks
D. PassarellaPrimo
2010
Abstract
The use of pharmaceutically active natural products as building blocks for the generation of new entities is a challenging strategy for the exploration of the chemical space. The presentation will regard three different topics: a) Synthesis of new camptothecin derivatives obtained by modification of position 20, b) Tubulin assisted dynamic combinatorial library of thiocolchicine-podophyllotoxin conjugates and c) Flow total synthesis of (+)-dumetorine and natural congeners
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