To characterize diffuse large B-cell lymphoma (DLBCL) with chromosome 7 gains, we combined clinical data with genomic, RNA and miRNA profiling. Gains were associated with age >60years, female gender, a trend for higher complete response rate, lower death rate, and better overall survival in patients treated with R-CHOP. Lesions were inversely associated with bone marrow involvement and number of extra-nodal sites. Differentially expressed transcripts were enriched of genes belonging to specific pathways and miRNAs targets. MIR96, MIR182, MIR589, MIR25 were shown significantly up-regulated in 7q+ DLBCL by real-time PCR.
Integrated profiling of diffuse large B-cell lymphoma with 7q gain / E. Chigrinova, M. Mian, Y. Shen, T.C. Greiner, W.C. Chan, J.M. Vose, G. Inghirami, A. Chiappella, L. Baldini, M. Ponzoni, A.J. Ferreri, S. Franceschetti, G. Gaidano, A. Tucci, F. Facchetti, T. Lazure, O. Lambotte, S. Montes Moreno, M.A. Piris, E. Zucca, I. Kwee, F. Bertoni. - In: BRITISH JOURNAL OF HAEMATOLOGY. - ISSN 0007-1048. - 153:4(2011 May), pp. 499-503. [10.1111/j.1365-2141.2011.08628.x]
Integrated profiling of diffuse large B-cell lymphoma with 7q gain
L. Baldini;
2011
Abstract
To characterize diffuse large B-cell lymphoma (DLBCL) with chromosome 7 gains, we combined clinical data with genomic, RNA and miRNA profiling. Gains were associated with age >60years, female gender, a trend for higher complete response rate, lower death rate, and better overall survival in patients treated with R-CHOP. Lesions were inversely associated with bone marrow involvement and number of extra-nodal sites. Differentially expressed transcripts were enriched of genes belonging to specific pathways and miRNAs targets. MIR96, MIR182, MIR589, MIR25 were shown significantly up-regulated in 7q+ DLBCL by real-time PCR.
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