Amiodarone-induced rosacea

Amiodarone is an anti-arrhythmic agent. Its most common cutaneous side effects are photosensitivity and hyperpigmentation. Furthermore, amiodarone rarely causes allergic rash, exfoliative dermatitis, toxic epidermal necrolysis, leucocytoclastic vasculitis, pseudoporphyria, linear IgA bullous dermatosis, vegetating iododerma and myxoedema. An increased susceptibility to the development of basal cell carcinomas was also reported. Only one case of rosacea due to amiodarone was reported so far. We describe a case of papulo-pustular rosacea which appeared four months after the beginning of the therapy with amiodarone. The disease did not improve despite several topical and oral therapies. However, it improved within six weeks after amiodarone discontinuation and completely cleared up within three months. Follow-up at one year was negative.