Two highly versatile isoxazoline derivatives, as key intermediates for the synthesis of differently functionalized subtype-selective N-methyl-d-aspartate receptor antagonists, were designed and synthesized. The synthetic strategy is based on an intramolecular nitrile oxide cycloaddition reaction which is a powerful method capable of controlling both the regio- and stereochemistry of the pericyclic reaction.
Regioselective Preparation of Functionalized Isoxazoline Derivatives, Key Intermediates in the Synthesis of Selective NMDA Receptor Antagonists / L. Tamborini, A. Pinto, P. Conti, M. Gallanti, M.C. Iannuzzi, L. Lo Presti, C. De Micheli. - In: SYNTHESIS. - ISSN 0039-7881. - 2011:8(2011 Apr), pp. Z52810SS.1255-Z52810SS.1260. [10.1055/s-0030-1258477]
Regioselective Preparation of Functionalized Isoxazoline Derivatives, Key Intermediates in the Synthesis of Selective NMDA Receptor Antagonists
L. Tamborini
Primo
;A. PintoSecondo
;P. Conti;M. Gallanti;M.C. Iannuzzi;L. Lo PrestiPenultimo
;C. De MicheliUltimo
2011
Abstract
Two highly versatile isoxazoline derivatives, as key intermediates for the synthesis of differently functionalized subtype-selective N-methyl-d-aspartate receptor antagonists, were designed and synthesized. The synthetic strategy is based on an intramolecular nitrile oxide cycloaddition reaction which is a powerful method capable of controlling both the regio- and stereochemistry of the pericyclic reaction.File | Dimensione | Formato | |
---|---|---|---|
Synthesis.2011.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
157.18 kB
Formato
Adobe PDF
|
157.18 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.