DC-SIGN and Langerin are two C-type lectins involved in the initial steps of HIV infections: the former acts as a viral attachment factor and facilitates viral invasion of the immune system, the latter has a protective effect. Potential antiviral compounds targeted against DC-SIGN were synthesized using a common fucosylamide anchor. Their DC-SIGN affinity was tested by SPR and found to be similar to that of the natural ligand Lewis-X (Le X). The compounds were also found to be selective for DC-SIGN and to interact only weakly with Langerin. These molecules are potentially useful therapeutic tools against sexually transmitted HIV infection.
Second generation of Fucose-based DC-SIGN ligands : affinity improvement and specificity versus Langerin / M. Andreini, D. Doknic, I. Sutkeviciute, J.J. Reina Martín, J. Duan, E. Chabrol, M. Thepaut, E. Moroni, F. Doro, L. Belvisi, J. Rojo, J. Weiser, F. Fieschi, A. Bernardi. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - 9:16(2011), pp. 5778-5786. [10.1039/C1OB05573A]
Second generation of Fucose-based DC-SIGN ligands : affinity improvement and specificity versus Langerin
M. AndreiniPrimo
;D. DoknicSecondo
;J.J. Reina Martín;E. Moroni;F. Doro;L. Belvisi;A. BernardiUltimo
2011
Abstract
DC-SIGN and Langerin are two C-type lectins involved in the initial steps of HIV infections: the former acts as a viral attachment factor and facilitates viral invasion of the immune system, the latter has a protective effect. Potential antiviral compounds targeted against DC-SIGN were synthesized using a common fucosylamide anchor. Their DC-SIGN affinity was tested by SPR and found to be similar to that of the natural ligand Lewis-X (Le X). The compounds were also found to be selective for DC-SIGN and to interact only weakly with Langerin. These molecules are potentially useful therapeutic tools against sexually transmitted HIV infection.File | Dimensione | Formato | |
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