All living organisms are constantly exposed to oxidant agents deriving from both endogenous and exogenous sources capable to modify biomolecules and induce damages. Free radicals generated by oxidative stress exert an important role in the development of tissue damage and aging. Reactive species (RS) derived from oxygen (ROS) and nitrogen (RNS) pertain to free radicals family and are constituted by various forms of activated oxygen or nitrogen. RS are continuosly produced during normal physiological events but can be removed by antioxidant defence mechanism: the imbalance between RS and antioxidant defence mechanism leads to modifications in cellular membrane or intracellular molecules. In this chapter only endogenous antioxidant molecules will be critically discussed, such as Glutathione, Alpha-lipoic acid, Coenzyme Q, Ferritin, Uric acid, Bilirubin, Metallothioneine, L-carnitine and Melatonin.

Endogenous Antioxidants and Radical Scavengers / A.M. Rizzo, P. Berselli, S. Zava, G. Montorfano, M. Negroni, P.A. Corsetto, B. Berra (ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY). - In: Bio-Farms for Nutraceuticals[s.l] : Springer, 2010. - ISBN 978-1-4419-7346-7. - pp. 52-67

Endogenous Antioxidants and Radical Scavengers

A.M. Rizzo
Primo
;
P. Berselli
Secondo
;
S. Zava;G. Montorfano;M. Negroni;P.A. Corsetto
Penultimo
;
B. Berra
Ultimo
2010

Abstract

All living organisms are constantly exposed to oxidant agents deriving from both endogenous and exogenous sources capable to modify biomolecules and induce damages. Free radicals generated by oxidative stress exert an important role in the development of tissue damage and aging. Reactive species (RS) derived from oxygen (ROS) and nitrogen (RNS) pertain to free radicals family and are constituted by various forms of activated oxygen or nitrogen. RS are continuosly produced during normal physiological events but can be removed by antioxidant defence mechanism: the imbalance between RS and antioxidant defence mechanism leads to modifications in cellular membrane or intracellular molecules. In this chapter only endogenous antioxidant molecules will be critically discussed, such as Glutathione, Alpha-lipoic acid, Coenzyme Q, Ferritin, Uric acid, Bilirubin, Metallothioneine, L-carnitine and Melatonin.
Settore BIO/10 - Biochimica
2010
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/160831
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