Relationship between metabolic and hemostatic variable in uncomplicated diabetes

Several metabolic (HbA1, HDL-C, triglycerides) and hemostatic (VIIIR:Ag, VIII:C, B-TG) variables were investigated in 35 non-obese, insulin-dependent diabetics without clinically evident vascular complications. B-TG was high but did not correlate with other metabolic and hemostatic parameters, suggesting that elevated B-TG in diabetes might be an expression of in vitro platelet activation. VIIIR:Ag and the ratio of VIIIR:Ag to VIII:C were markedly increased. There was a significant correlation of the HbA1 and HDL-C levels with VIIIR: Ag, indicating that VIIIR:Ag is another reflection of metabolic control in diabetes. Additional pathogenic mechanisms, however, appear to be involved in causing the changes in VIIIR: Ag in diabetes.