An injection-molded swellable/erodible hydroxy-propylcellulose (HPC)-based capsular device for oral pulsatile delivery was prepared, evaluated in terms of in vitro performance and subjected to a preliminary in vivo investigation. The system prepared was proven able to delay the onset of release for periods of time that turned out correlated with the shell thickness. Administered to healthy volunteers, it yielded drug concentration profiles characterized by lag time values that were in linear relationship with the in vitro ones.
Injection-Molded Capsular Device for Oral Pulsatile Delivery : an In Vivo Evaluation / A. Gazzaniga, A. Foppoli, A. Maroni, A. Cozzi, E. Macchi, M. Cerea - In: Proceedings of 2011 CRS Annual Meeting and Exposition[s.l] : CRS (Controlled Release Society), 2011 Jul. (( Intervento presentato al 38. convegno Annual Meeting & Exposition of the Controlled Release Society tenutosi a National Harbor (US-MD) nel 2011.
Injection-Molded Capsular Device for Oral Pulsatile Delivery : an In Vivo Evaluation
A. GazzanigaPrimo
;A. FoppoliSecondo
;A. Maroni;E. MacchiPenultimo
;M. CereaUltimo
2011
Abstract
An injection-molded swellable/erodible hydroxy-propylcellulose (HPC)-based capsular device for oral pulsatile delivery was prepared, evaluated in terms of in vitro performance and subjected to a preliminary in vivo investigation. The system prepared was proven able to delay the onset of release for periods of time that turned out correlated with the shell thickness. Administered to healthy volunteers, it yielded drug concentration profiles characterized by lag time values that were in linear relationship with the in vitro ones.
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