Human Exo1 is required to activate the checkpoint response after UV irradiation in human cells. hExo col-localizes with NER factors at the sites of UV lesions and hEXO1 down-regulation by siRNA technology affects DNA repair synthesis.
Human exonuclease 1 connects the ner response and the checkpoint activation after UV induced DNA damage / S. Sertic ; tutor: P. Plevani ; coordinator: R. Mantovani. DIPARTIMENTO DI SCIENZE BIOMOLECOLARI E BIOTECNOLOGIE, 2010. 22. ciclo, Anno Accademico 2008/2009.
Human exonuclease 1 connects the ner response and the checkpoint activation after UV induced DNA damage
S. Sertic
2010
Abstract
Human Exo1 is required to activate the checkpoint response after UV irradiation in human cells. hExo col-localizes with NER factors at the sites of UV lesions and hEXO1 down-regulation by siRNA technology affects DNA repair synthesis.
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