Anxiety disorders are common psychiatric conditions that typically require long-term treatment. This review summarizes current knowledge of the pharmacological treatment of anxiety disorders with serotonin norepinephrine reuptake inhibitors (SNRIs) with specific emphasis on the findings of recent randomized clinical trials and relevant neurobiological investigations. It is now well established that gabaergic, noradrenergic and serotonergic systems play a critical role in the pathophysiology of anxiety disorders, abnormalities in these systems being related to structural and functional alterations in specific brain areas such as the amygdala, prefrontal cortex, locus coeruleus and hippocampus, as repeatedly shown by neuroimaging studies. SNRIs selectively inhibit norepinephrine and serotonin reuptake and have shown to be efficacious and generally well tolerated treatments in patients with anxiety disorders, with some potential clinical advantages over selective serotonin reuptake inhibitors (SSRIs), which are considered by many to represent first-line pharmacological treatments in patients with anxiety disorders. Anxiety disorders are characterized by a typically chronic course, high rates of comorbidity and frequent partial response to standard treatments, and the increasing use of SNRIs reflects currently unmet clinical need, in terms of overall response, remission rates and treatment tolerability

Serotonin norepinephrine reuptake inhibitors (SNRIs) in anxiety disorders : a comprehensive review of their clinical efficacy / B. Dell'Osso, M. Buoli, D.S. Baldwin, A.C. Altamura. - In: HUMAN PSYCHOPHARMACOLOGY. - ISSN 0885-6222. - 25:1(2010 Jan), pp. 17-29.

Serotonin norepinephrine reuptake inhibitors (SNRIs) in anxiety disorders : a comprehensive review of their clinical efficacy

B. Dell'Osso
Primo
;
M. Buoli
Secondo
;
A.C. Altamura
Ultimo
2010

Abstract

Anxiety disorders are common psychiatric conditions that typically require long-term treatment. This review summarizes current knowledge of the pharmacological treatment of anxiety disorders with serotonin norepinephrine reuptake inhibitors (SNRIs) with specific emphasis on the findings of recent randomized clinical trials and relevant neurobiological investigations. It is now well established that gabaergic, noradrenergic and serotonergic systems play a critical role in the pathophysiology of anxiety disorders, abnormalities in these systems being related to structural and functional alterations in specific brain areas such as the amygdala, prefrontal cortex, locus coeruleus and hippocampus, as repeatedly shown by neuroimaging studies. SNRIs selectively inhibit norepinephrine and serotonin reuptake and have shown to be efficacious and generally well tolerated treatments in patients with anxiety disorders, with some potential clinical advantages over selective serotonin reuptake inhibitors (SSRIs), which are considered by many to represent first-line pharmacological treatments in patients with anxiety disorders. Anxiety disorders are characterized by a typically chronic course, high rates of comorbidity and frequent partial response to standard treatments, and the increasing use of SNRIs reflects currently unmet clinical need, in terms of overall response, remission rates and treatment tolerability
serotonin norepinephrine reuptake inhibitors (SNRIs); anxiety disorders (ADs); selective serotonin reuptake inhibitors (SSRIs)
Settore MED/25 - Psichiatria
gen-2010
Article (author)
File in questo prodotto:
File Dimensione Formato  
dell'osso, buoli et al, 2010.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 134.17 kB
Formato Adobe PDF
134.17 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/153704
Citazioni
  • ???jsp.display-item.citation.pmc??? 22
  • Scopus 70
  • ???jsp.display-item.citation.isi??? 65
social impact