We disclose preliminary data of an ongoing pilot study in rice and maize cultivations in Lombardy (Italy) which use propanil and terbuthylazine as herbicide treatments. 24 small farms (one worker per farm) volunteered into the study. Pads positioned above and below clothing were employed to measure dermal exposure to agrochemicals during application and urine analysis was employed to measure its absorption through excretion of the main metabolites in pre- and post-application 24-hour urine samples. The study estimated that the workers’ median levels of whole-body exposure to spray-applied propanil was of 0.032 (0.01-1.24) parts-per-million of applied agrochemical. Referring to 24-hour post-application excretion of the main metabolite of propanil, 3,4 dichloroaniline, the median absorbed dose resulted of approx. 0.3 parts-per-million of applied propanil, corresponding to approx. 0.18 microg/kg of body weight of the examined farmers. Compared to the health-based AOEL of 70 microg/kg/die of body weight defined in the authorization warrant, this value allows to assess that these workers are facing a toxicologically unrelevant exposure. BM was able to highlight the accidentally high absorption (100-fold higher) of propanil by one farmer who splashed himself during preparation or application and that also this worker was safely within the AOEL.

Integrazione di monitoraggio ambientale e biologoico e della stima modellistica dell’esposizione per la valutazione del rischio da prodotti chimici degli agricoltori / F.M.R. Rubino, C. Colosio, M. Bogni, E. Ariano, G. Brambilla, G. De Paschale, A. Firmi, C. Minoia, S. Savi, C. Somaruga, R. Turci, F. Vellere, A. Colombi. - In: GIORNALE ITALIANO DI MEDICINA DEL LAVORO ED ERGONOMIA. - ISSN 1592-7830. - 31:4 (suppl. 2)(2010 Oct), pp. 420-421. ((Intervento presentato al 73. convegno Congresso Nazionale della Società Italiana di Medicina del Lavoro ed Ergonomia : La Medicina del lavoro quale elemento migliorativo per la tutela e sicurezza del lavoratore e delle attività dell’impresa tenutosi a Roma nel 2010.

Integrazione di monitoraggio ambientale e biologoico e della stima modellistica dell’esposizione per la valutazione del rischio da prodotti chimici degli agricoltori

F.M.R. Rubino;C. Colosio;M. Bogni;G. Brambilla;C. Somaruga;F. Vellere;A. Colombi
2010

Abstract

We disclose preliminary data of an ongoing pilot study in rice and maize cultivations in Lombardy (Italy) which use propanil and terbuthylazine as herbicide treatments. 24 small farms (one worker per farm) volunteered into the study. Pads positioned above and below clothing were employed to measure dermal exposure to agrochemicals during application and urine analysis was employed to measure its absorption through excretion of the main metabolites in pre- and post-application 24-hour urine samples. The study estimated that the workers’ median levels of whole-body exposure to spray-applied propanil was of 0.032 (0.01-1.24) parts-per-million of applied agrochemical. Referring to 24-hour post-application excretion of the main metabolite of propanil, 3,4 dichloroaniline, the median absorbed dose resulted of approx. 0.3 parts-per-million of applied propanil, corresponding to approx. 0.18 microg/kg of body weight of the examined farmers. Compared to the health-based AOEL of 70 microg/kg/die of body weight defined in the authorization warrant, this value allows to assess that these workers are facing a toxicologically unrelevant exposure. BM was able to highlight the accidentally high absorption (100-fold higher) of propanil by one farmer who splashed himself during preparation or application and that also this worker was safely within the AOEL.
agrochemicals ; biological monitoring ; environmental monitoring ; exposure modelling ; risk assessment
Settore MED/44 - Medicina del Lavoro
ott-2010
Società Italiana di Medicina del Lavoro e Igiene Industriale
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/153599
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