Inefficient immune recovery under highly active antiretroviral therapy (HAART) represents a clinical issue. Twenty-seven of 121 HIV+ naïve patients became immunological nonresponders (INRs) and 55 introduced therapy late [very late treated (VLT)]. INR displayed older age, lower CD4(+) cell counts, down-regulation of CD127(+)CD4(+) and higher apoptotic CD95(+)CD8(+). VLT also showed higher activated CD38(+)CD8(+)%. The only factor associated with INR status was CD127(+)CD4(+)%. INR showed lower baseline interleukin (IL)-7 levels and a reduced expression of IL-7R (CD127(+)) on naïve and memory T-cells, reaching significance in memory CD127(+)CD45(+)R0(+)CD4(+). These results suggest a possible role for the IL-7/IL-7R system in the pathogenesis of poor immunological recovery during HAART.

Reduced CD127 expression on peripheral CD4+ T cells impairs immunological recovery in course of suppressive HAART / F. Bai, G.M. Bellistrì, C. Tincati, A. Savoldi, A. Pandolfo, T. Bini, G. Carpani, E. Sinigaglia, G. Marchetti, A. D’Arminio Monforte. - In: AIDS. - ISSN 0269-9370. - 24:16(2010 Oct 23), pp. 2590-2593. [10.1097/QAD.0b013e32833f9d64]

Reduced CD127 expression on peripheral CD4+ T cells impairs immunological recovery in course of suppressive HAART

F. Bai
Primo
;
G.M. Bellistrì;C. Tincati;G. Marchetti
Penultimo
;
A. D’Arminio Monforte
Ultimo
2010

Abstract

Inefficient immune recovery under highly active antiretroviral therapy (HAART) represents a clinical issue. Twenty-seven of 121 HIV+ naïve patients became immunological nonresponders (INRs) and 55 introduced therapy late [very late treated (VLT)]. INR displayed older age, lower CD4(+) cell counts, down-regulation of CD127(+)CD4(+) and higher apoptotic CD95(+)CD8(+). VLT also showed higher activated CD38(+)CD8(+)%. The only factor associated with INR status was CD127(+)CD4(+)%. INR showed lower baseline interleukin (IL)-7 levels and a reduced expression of IL-7R (CD127(+)) on naïve and memory T-cells, reaching significance in memory CD127(+)CD45(+)R0(+)CD4(+). These results suggest a possible role for the IL-7/IL-7R system in the pathogenesis of poor immunological recovery during HAART.
viral suppression; late presenters; activation; responses; interleukin-7; infection; HAART; CD38; ERA
Settore MED/17 - Malattie Infettive
23-ott-2010
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/150651
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